Sangoma Endpoint Manager module on FreePBX 16 was licensed for 25 years, but now it's asking for renewal and has been has been disabled by Sangoma

What version of the module are you running ? You can find this in the Module Admin page of the web interface. (Screenshots of the list of modules and other warning/error messages would be helpful as well.)

Also, are you only using the official Sangoma FreePBX mirror servers ? See this post for more details about security and other problems with alternatives: Avoid walking the plank with expired modules