Remote handsets suddenly cant connect

What kind of handsets?
VPN?
NAT?
Router Reset?
SIP-ALG?
FreePBX Version?
Port on the phone or port on the server?
Destination?
How are you figuring this out?

Something had to change.

I changed that to “now”, since “not” was just confusing.

What do you mean by this? This kind of stuff doesn’t “just happen”. Something changed.

Also, the port numbers on both ends of the connection are independent, so which port numbers are you talking about? Also, NAT will change the port that the server sees as the port for the phone at the remote end, so that setting might make perfect sense.

Are you saying the phones are trying to register on ports that are not 5060, or are you saying that the phones are listening on different ports now and that you are trying to connect to them on port 5060?