Retransmission timeout reached on transmission

I have a client who works with freepbx which is installed on the cloud
the cloud and the customer’s network are in VPN
the line does not seem to have falls is stable and does not lose packages …
yet look at this error …:

([2018-11-15 12:15:12] WARNING [1985] chan_sip.c: Retransmission timeout reached on transmission [email protected] for seqno 102 (Critical Request) - See https : //wiki.asterisk.org/wiki/display/AST/SIP+Retransmissions

Packet timed out after 6400ms with no response

[2018-11-15 12:15:12] WARNING [1985] chan_sip.c: Hanging up call [email protected] - no reply to our critical packet (see https: // wiki .asterisk.org / wiki / display / AST / SIP + Retransmissions).)

Obviously the call falls …

The configuration of the firewall of course I have verified it is simple and can not generate this problem …

FreePBX I just uploaded the local networks in vpn as 192.168.1.0/24 192.168.10.0/24 192.168.10.0/24
These three are the three local networks in vpn of the client

Should I leave NAT active?

Where could the problem be …?

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