Problems with tls-pjsip calls

Dear community.
We use FreePBX-10.13.66-15 distro build. Some extensions are configured for tls-pjsip and sometimes when users call each other, the call is interrupted and we see in the log the following errors:

ERROR[2482] pjproject: tlsc0x7f9264b0 TLS connect() error: Connection refused [code=120111]
WARNING[2482] pjproject: tsx0x7f926c02a Failed to send Request msg INVITE/cseq=20315 (tdta0x7f926c0524c0)! err=120111 (Connection refused)

It occures not permanently, but from time to time and without of any changes in sip - clients and server configurations.
What could be the problem?