There are some “unusual” things in your output.
The first (and scariest) is that your 501 extension is coming in from 10.x.x.x while your system otherwise appears to be connected to 192.168.x.x. There’s some odd routing within the 192.168 address as well. You have one subnet set up as 192.168.100.x and one set up as 192.168.101.x. Your server appears to be getting through to them alright, though, so the networking issues are probably not a big part of the issues.
It appears that you have outbound route set up as a restricted route. I’m going to guess a PIN Number or you limited the outbound route with a required extension? Maybe you have an IP Address allow/deny pair that’s in your way?
So, to get started, I recommend removing the matching pattern on your outbound route that is set up in your trunk. At the same time, remove the matching pattern on your trunk (If you have one).
Once you are done with that, try calling from your local extensions. Call from 500 to 501. Then, try 501 to 500. Make sure you get good connections (sound and everything).
Once that’s working, dial a number you know should be working outside of your network. Time and temperature at a bank are usually pretty good. If you can, find a number that you can connect to that doesn’t actually require you to do anything. Check the outcome of that connection in the logs.
The page “Sangoma Documentation” has some good information about restricted routes.